Abstract

EFFECTS OF PALM DATES (PHOENIX DACTYLIFERA L) EXTRACTS ON HEPATIC DYSFUNCTIONS IN TYPE 2 DIABETIC RAT MODEL

Abdelaziz M. Hussein*, Amani M.D. El-Mousalamy, Sahar A. M. Hussein and Seham A. Mahmoud

ABSTRACT

Phoenix dactylifera L is one of the most useful traditional medicinal plants. Previous studies demonstrated that it has many pharmacological actions such as antibacterial, anti-inflammatory, anti-diabetic, anti-asthamatic, nephroprotective and hepatoprotective activities. Moreover, previous studies demonstrated that its fruits and seeds contain many chemical substances such as anthocyanins, phenolics, sterols, carotenoids and flavonoids. So, the present study was designed to analyze its phenolics and flavonoids contents using HPLC – PDA as well as to investigate the protective properties of palm date extracts on liver functions in type 2 diabetic rats. The results of this study revealed that the extracts of palm dates contain phenolic compounds caffeic, gallic, ferulic, p-coumaric, sinapic, chlorogenic acid and falvonoid compounds Apegenin, Quercetin and luteolin glycosides in fruit extracts and vanillic acid, gallic acid, caffeic acid, p-Coumaric acid and quercitin in seede extracts. Also, both fruit and seed extracts caused significant improvement in glycaemic control and liver functions in diabetic rats. We concluded that both fruit and seed extracts have hepatoprotective effect in type 2 diabetic rats which might be due to their phenolics and flavonoids contents.

Keywords: Phoenix dactylifera; phenolics; flavonoids glycoside, High Performance Liquid Chromatography (HPLC); diabetes and hepatoprotective.