Abstract

THIADIAZOLE: A BRIEF REVIEW

Samiksha Srivastava*, Raj K. Prasad, Rakesh Saini

ABSTRACT

Thiadiazole is a heterocyclic compound and exhibits a wide variety of pharmacological activities such as anticancer, antitubercular, antibacterial, antifungal, antimicrobial, anti‐inflammatory, analgesic, anticonvulsant, diuretic and anti-secretory activities. It occur in nature in four isomeric forms as 1,2,3-thiadiazole; 1,2,5-thiadiazole; 1,2,4-thiadiazole and 1,3,4-thiadiazole. Differently substituted thiadiazole moieties have different activity. In this article we have discussed about different isomers of thiadiazole and their properties, various method of synthesizing different isomers of thiadiazole and several pharmacological activity of 1,3,4-thiadiazole.

Keywords: Heterocyclic compound, thiadiazole, 1,3,4-thiadiazole, properties, synthesis, pharmacological activity.