Abstract

FORMULATION AND EVALUATION OF SOLID-SELF NANO EMULSIFYING DRUG DELIVERY SYSTEM (S-SNEDDS) FOR GLIBENCLAMIDE

Sreenivas Patro Sisinthy* and Chua Hui Jen

ABSTRACT

Glibenclamide (GBD) is one of the most prescribed long-acting anti hyperglycaemic agent used in the treatment of treat Type 2 diabetes mellitus. GBD is a poorly soluble drug which results in low bioavailability. Hence, the objective of the study is to develop a solid self-nano emulsifying drug delivery system (S-SNEDDS) to improve the solubility and dissolution rate of GBD. Liquid SNEDDS was prepared using Maisine-35-1 as oil, Cremophor RH40 as surfactant, and PEG 400 as cosurfactant. Ternary phase diagrams were constructed to identify the self-nano emulsification region. Based on the phase diagrams, few formulations containing 10-25% of oil were prepared by simple mixing and vortexing. These formulations were adsorbed onto Neusilin US2 to produce solid SNEDDS and were evaluated for drug content, globule size, zeta potential and in vitro drug release. DSC and FTIR studies were also performed and the results indicated that there were no incompatibilities between GBD and the components in the SNEDDS. The prepared formulations exhibited a globule size ranging from 14.14 to 45.36 nm. In vitro dissolution profiles showed that dissolution rate of Glibenclamide from liquid and solid SNEDDS was much greater when compared to the pure drug and the marketed tablet. Thus, this study indicated that the solid SNEDDS could be used as a potential drug carrier for GBD with improved solubility and dissolution rate.

Keywords: Glibenclamide, SNEDDS, Neusilin US2, Maisine-35-1, Cremophor RH40, PEG400.