Abstract

SYNTHESIS AND FLUORESCENCE STUDY OF A SERIES OF 4-HYDROXYCOUMARIN O-ACYLATION DERIVATIVES

Abdoulaye Djandé*, Lamine Cissé, Jules Yoda, Léopold Kaboré and Fabrice Duvernay

ABSTRACT

Some coumarin derivatives were synthesized starting from 4-hydroxycoumarin and benzoyl chlorides. The structures of the obtained compounds were confirmed by mass and NMR spectra. Additionally, their crystal structures were determined by X-ray diffractometry, excepting the compound C1. Absorption and fluorescence spectra of these derivatives have been investigated in acetonitrile medium. The effects of various electron donating substituents R on fluorescence emission were examined. As a result, compound C5 with an electron-donating substituent dimethyl amino (R = Me2N) exhibited the strongest fluorescence.

Keywords: 4-hydroxycoumarin, O-acylation, (coumarin-4-yl)-benzoates, fluorescence, substituent R.