Abstract

EFFECTS OF FLAVONOIDS EXTRACTED FROM ARTEMISIA VULGARIS ON INDUCED HYPERURICEMIA IN MICE

Nawar Aziz Alkhafaji* and Abdulkareem H. Abd

ABSTRACT

Objective: The aim of the study was to investigate the hypouricemic effect of flavonoids extracted from aerial parts of Artemisia vulgaris on hyperuricemic mice. Methods: Forty albino mice were divided into four groups. Mice were orally administered either vehicle, allopurinol (20 mg/kg), flavonoids of Artemisia vulgaris 500 mg/kg for seven consecutive days. On the 7th day, all mice except control were injected with uric acid 250 mg/kg intraperitoneally then serum uric acid, creatinine and Glutathione were determined. Morphological changes in kidney were observed using hematoxylin and eosin staining. Results: results showed that flavonoids fraction of Artemisia vulgaris significantly reduced the serum uric acid level in hyperuricemic mice. Conclusion: flavonoids extracted from aerial parts of Artemisia vulgaris have hypouricemic effect.

Keywords: Hyperuricemia, Artemisia vulgaris, Uric acid, Xanthine oxidase, Gout, Allopurinol.