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Ereny Samuel*, Ahmed S. Shehata, Mohamed Abdel Wahab and A. F. Abdel-Aziz


Background: Besides, cost/effectiveness and efficacy of surveillance and screening of patients with cirrhotic liver for the diagnosis of hepatocellular carcinoma (HCC) is still debated. Search for suitable biomarkers of HCC is very intense. Roles of activated leucocyte cell adhesion molecule (ALCAM) in HCC diagnosis are largely unknown. This study aimed to investigate clinical diagnostic power of serum ALCAM to discriminate HCC patients from non-malignant cirrhotic patients. Methods: Activated leucocyte cell adhesion molecule was tested for 50 HCC patients, 30 cirrhotic patients and 25 healthy individuals by enzyme-linked immunosorbent assay (ELISA). Data from all participants were retrospectively analyzed and receiver operating characteristic (ROC) curve was established to evaluate ALCAM value as HCC biomarker. Results: Hepatocellular carcinoma patients were associated with significantly (P<0.001) higher ALCAM serum levels than cirrhotic and healthy controls. Serum ALCAM has high HCC diagnostic power with AUC of 0.963, sensitivity 90%, specificity 91%, positive predictive value 90%, negative predictive value 90.9% and accuracy 90.5%. Elevated ALCAM levels were associated with multiple nodes and large tumors (>3cm). Also, ALCAM levels were Significantly correlated with ALT, AST, albumin, total bilirubin, AFP and also with oxidative stress parameters include catalase (CAT), total antioxidant capacity (TAC) and malondialdehyde (MDA). Conclusions: Our results indicate that serum ALCAM might be served as a potential biomarker with high diagnostic value for HCC screening.

Keywords: Hepatocellular carcinoma, Diagnosis, Biomarker, ALCAM, Oxidative stress.

[Full Text Article]

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