Abstract

EFFECT OF POLYHERBAL FORMULATION RHEUMATONE ON ENZYMATIC ANTIOXIDANT LEVELS IN LIVER AND KIDNEY OF FREUND’S COMPLETE ADJUVANT (FCA) INDUCED ARTHRITIC RATS

*S. Shamina

Assistant Professor, Dept of Biochemistry, RVSCAS, Coimbatore, Tamilnadu, India.

ABSTRACT

Background: Rheumatoid arthritis is a chronic systemic inflammatory disease that is associated with the long term disability and premature mortality. Although a number of drugs (non-steroidal or steroidal anti-inflammatory agents and immunosuppressants) used in the treatment of RA, there is still an urgent need for more effective drugs with lower side effects. The acute stage of arthritis is characterized by signs of lack of mobility and pause in body weight gain. Findings: A polyherbal formulation(Rheumatone) was made using five medicinal plants namely Clitorea ternatea, Sida cordifolia, Cleodendron serratum, Bacopa monnieri, Cardiospermum halicacabum. There is a significant reduction (p

Keywords: Super oxide dismutase Glutathione peroxidase, Freund’s Complete Adjuvant, Rheumatoid arthritis.