Abstract

EFFECT OF POLYHERBAL FORMULATION RHEUMATONE ON ENZYMATIC ANTIOXIDANT LEVELS IN LIVER AND KIDNEY OF FREUND’S COMPLETE ADJUVANT (FCA) INDUCED ARTHRITIC RATS

*S. Shamina

Assistant Professor, Dept of Biochemistry, RVSCAS, Coimbatore, Tamilnadu, India.

ABSTRACT

Background: Rheumatoid arthritis is a chronic systemic inflammatory disease that is associated with the long term disability and premature mortality. Although a number of drugs (non-steroidal or steroidal anti-inflammatory agents and immunosuppressants) used in the treatment of RA, there is still an urgent need for more effective drugs with lower side effects. The acute stage of arthritis is characterized by signs of lack of mobility and pause in body weight gain. Findings: A polyherbal formulation(Rheumatone) was made using five medicinal plants namely Clitorea ternatea, Sida cordifolia, Cleodendron serratum, Bacopa monnieri, Cardiospermum halicacabum. There is a significant reduction (p<0.001) in the levels of Super oxide dismutase(SOD), Catalase, Peroxidase and Glutathione peroxidase(GPx) in the liver and kidney of adjuvant induced arthritic rats and there is an elevated level of SOD, Catalase, Peroxidase (p< 0.001) noted in the Liver and Kidney of rats that were treated with the polyherbal formulation Rheumatone compared with the toxic rats. There is a signiciant increase of GPx(p< 0.01) in Liver and Kidney of rats treated with Rheumatone compared with Group II rats treated with Freund’s Complete Adjuvant (FCA). Conclusions: The study confirms that the polyerbal formulation Rheumatone made from Clitorea ternatea, Sida cordifolia, Cleodendron serratum, Bacopa monnieri, Cardiospermum halicacabum does not exhibit any side effects and it has the enzymatic antioxidant activity.

Keywords: Super oxide dismutase Glutathione peroxidase, Freund’s Complete Adjuvant, Rheumatoid arthritis.