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Abstract

POLYMORPHISM IN PHARMACEUTICAL INGREDIENTS A REVIEW

*Ethiraj Thiruvengadam and Ganeshan Vellaisamy

ABSTRACT

When formulating a drug product, physico-chemical stability, solubility and bio-availability of active pharmaceutical ingredient (API) is an important impact. The knowledge of solid-state properties of API in an early stage of drug development helps to avoid the manufacturing defects and to improve its qualities. This makes the study of polymorphism and crystallization of pharmaceutical compounds highly important. Now-a-days, most of the drugs are formulated in crystalline form, so the manufacturing units highly concentrate on the investigation of crystal polymorphism to optimize the physico-chemical properties of API before the drug product development. It is necessary to get knowledge about the polymorphism in order to achieve the rapid absorption of low solubility drugs in to systemic circulation, to improve the dissolution rate, to assure the stability of drug and to achieve the bio-availability. This article briefly reviews, the importance, application of polymorphism in pharmaceuticals, types of crystal systems & polymorphism and its characterization.

Keywords: Cyrstallization, Solubility, Stability and bio-availability


[Full Text Article]

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