Abstract

REVIEW ON ANALYTICAL METHOD VALIDATION OF NITROIMIDAZOLES

Mohammad Zameeruddin, Solanke S.B*., Kalyankar S.S., Jadhav S.B., Kadam V.S.,Bharkad V.B.

ABSTRACT

Imidazole is a planner five membered ring system with 3 carbon and 2 nitrogen atom in 1 and 3 position. It is soluble in water and other solvents. It presents in two equivalent tautomeric forms i.e the hydrogen atom is located on one of the two nitrogen atoms. Imidazole is entirely soluble in water and highly polar compound as evidenced by a calculated dipole of 3.61 D. It is colurless liquid having high boiling point of 2560C than all other 5 membered heterocyclic compound due to intermolecular H bonding where there is linear association of molecule. Imidazole drug have broadened scope in remedying various dispositions in clinical medicines. Medicinal properties of imidazole include anticancer .b-lactamase inhibitors, carboxypeptidase inhibitor, antiaging agent, anticoagulants, anti-inflammatory, antibacterial, antiviral, antifungal antitubercular, antidiabetic and antimalarial. Nitroimidazoles class of drugs are a well-established group of antiprotozoal and antibacterial agents that have ability to inhibit the growth of anaerobic bacteria and certain anaerobic protozoa, for example Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia. This review article presents determination of Ornidazole and Tinidazole was done by UV spectrophotometer, HPLC, potentiometry, calorimetry, titrimetry and HPTLC.

Keywords: Imidazole, Nitroimidazole, Ornidazole and Tinidazole