Abstract

ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF AGANOSMA CYMOSA ON FORMALIN INDUCED PAW EDEMA IN WISTAR RATS

Farmiza Begum*, T. Ravi Chander, P. Anitha, B. Keerthi

ABSTRACT

Inflammation is one of the most important processes involved in the defense of an organism against local injury and infections. However it often progress to painful or chronic harmful diseases requiring pharmacological treatment. Inflammatory response is a series of well coordinated dynamic mechanism consisting of specific vascular humoral and cellular events that is characterized by the movement of fluids plasma and inflammatory leukocytes to the site of inflammation. A variety of chemical mediators or signalling molecules such as histamine, serotonin, leukotrienes, prostaglandins and ROS are produced by inflammatory and Phagocytic cells predominantly in the sequences which participate in onset of inflammation. The Primary objective of this present study is to evaluate the anti-inflammatory activity of ethanol extract of leaves of Aganosma cymosa in male wistar rats. In this perspective Ethanolic extract of leaves of Aganosma cymosa was taken & Formalin induced paw edema model was selected for inducing inflammation & Diclofenac sodium is used as Standard. Statistical analysis was carried out by one-way analysis of variance followed by Dunnet’s test. The anti inflammatory activity of ethanolic extract of Aganosma cymosa at the doses of 150 and 300 mg/kg p.o. was evaluated by Formalin induced paw edema model in Rats. The results showed that, the Ethanolic extract significantly decreased the paw edema in a dose dependant manner and exhibited more activity at the dose of 300 mg/kg. The Ethanolic extract exhibited anti inflammatory activity, which may be due to the presence of phytoconstituents present in the extract. These findings justify the traditional use of this plant in the control and/or treatment of inflammation as the plant is unexplored yet. Further detailed phytochemical investigations are required to identify the phytoconstituent/s responsible for the anti inflammatory activity.

Keywords: Aganosma cymosa, anti-inflammatory effect, Formalin induced paw edema, Diazepam.