Abstract

DESIGN & DEVELOPMENT OF GASTRORETENTIVE SUPERPOROUS HYDROGEL TABLETS OF ESOMEPRAZOLE

Nagalaxmi P, Naga Sai D. and *Bhavani B.

ABSTRACT

Super porous hydrogel were designed to retain drug in gastric medium. These systems swell very rapidly in stomach & maintain their integrity for longer period even in acidic environment of stomach while releasing pharmaceutical ingredient. The present work focused on the concept to formulate super porous hydrogel tablets of esomeprazole using effervescent approach for gastro retentive drug delivery system to improve its bioavailability. The rate retarding polymers like chitosan, xanthum gum & tamarind gum along with other suitable excipients were used by direct compression method. The prepared tablets were evaluated for apparent density porosity, swelling studies, scanning electron microscopy, in vitro drug release, FTIR studies & stability studies. The results revealed that the selected formulation (F6 containing xanthum gum) successfully showed expected criteria for gastro retentive drug delivery system based on super porous hydrogel is promising for stomach specific delivery of esomeprazole.

Keywords: Gastro retentive, Super porous hydrogel, Swelling studies & Stability studies.