Abstract

SOLUBILITY ENHANCEMENT OF CEFIXIME THROUGH SOLID DISPERSION TECHNIQUE

S. K. Sadia*, Dr. M. Dhanalakshmi and B. Nageswar Rao

ABSTRACT

In the present study Cefixime solid dispersions were formulated. The enhancement of its solubility and dissolution profile is expected to significantly improve its bioavailability and reduce its side effects. Cefixime was mixed with various proportions of excipients showed no color change at the end of two months, proving no drug-excipient interactions. The pre compression blend of Cefixime solid dispersions were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. The precompression blend of all the batches indicates good to fair flowability and compressibility. Solid dispersions were prepared with various concentrations of carriers; the prepared solid dispersions were compressed into tablets. The formulated tablets were evaluated for various quality control parameters. The tablets were passed all the tests. Among all the formulations F8 formulation containing, Drug and PEG 6000 in the ratio of 1:4 showed good result that is 97.65% in 60 minutes. As the concentration of polymer increases the drug release was increased. While the formulations containing PEG 4000, 8000 showed less release. Hence from the dissolution data it was evident that F8 formulation is the optimized formulation.

Keywords: Cefixime, PEG 4000, PEG 6000, PEG 8000, Solid Dispersions.