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Abstract

A REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEM

Gajanan R.Kapse*, Kadam V.S , Jadhav S.B, Md. zameeruddin,Bharkad V.B, Shinde S.G.

ABSTRACT

This review explains the recent advances in gastroretentive drug delivery systems with special focus on floating drug delivery systems. Oral route is the most convenient and painless technique of drug delivery. Gastroretentive drug delivery systems have been developed which overcome physiological conditions in gastrointestinal tract such as short gastric resident time (GRT) and unpredictable gastric emptying times (GET). Various approaches used for prolonging GRT are mucoadhesive systems (Bioadhesive Systems), High Density Systems, Expandable Systems (Swelling Systems), Floating Drug Delivery systems (FDDS). formulations of floating tablets were prepared using direct compression technique with low viscosity polymer such as HPMC K100LV, high viscosity polymers such as HPMC K4M, K15M, and carbopol in different ratios. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, content uniformity, hardness, friability and buoyancy. Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. Incorporation of the drug in a controlled release gastroretentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would significantly prolong the gastric residence time of drugs and improve bioavailability, reduce drug waste, and enhance the solubility of drugs that are less soluble in high pH environment. Several approaches are currently utilized in the prolongation of the GRT, including floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bioadhesive systems, high-density systems, modified-shape systems and other delayed gastric emptying devices.

Keywords: Gastric retention time, Gastro retentive systems; floating drug delivery system; Effervescent; non effervescent.


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