Abstract

MICROSPHERE: A COMPLETE REVIEW

Dalbanjan Nikita S.*

ABSTRACT

This review gives a complete overview on how microspheres (particle size ranging from 1-1000 μm) have gained popularity for delivering a wide variety of molecules via various routes. These types of products have been prepared using various natural and synthetic polymers through suitable techniques for desired delivery of various challenging molecules. Microsphere are spherical microparticles, and are used where consistent and predictable particle surface area is important. A microsphere has a unique polymeric membrane encasing centrally located drug in it. Microspheric drug delivery system has gained enormous attention not only for prolonged release but also due to its wide range of application as it covers targeting the drug to particular site to imaging and helping the diagnostic features. Today by combining various other strategies, microspheres have found the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene & genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body. This review compiles various types of microspheres, polymers used, different methods to preparation, Factors influencing, various parameters to evaluate their efficiency, its applications, and also some Recent Advancements in Microspheres.

Keywords: Microspheres, microencapsulation, microencapsulation techniques, controlled drug delivery, solvent evaporation, supercritical fluid, Spray drying and spray congealing.