Abstract

MICRONEEDLES AS NOVEL APPROACH FOR DRUG DELIVERY SYSTEM

Hrushikesh Koria*, Arjun Dedakia, Ghansyam Patel

ABSTRACT

Microneedles were discovered before 100 years for conceptualized drug delivery systems, while the significantly research should be started in the 1990 while at that time the microbial fabrication technology should be enabled. The manufactures should be interested in skin permeability so first they interested in solid microneedles, the other like coated microneedles with dissolved drug, then the polymer microneedle encapsulated drug and fully dissolved in the skin and hollow microneedles for drug diffusion only. The microneedles are mainly useful for only those drugs which have a low molecular weight drugs and also for supplying of drug with protein drugs and vaccines. For example influenza vaccination in that hollow microneedle is clinically used and also used for the cosmetic purpose also. Now a day the microneedle s is used in the ocular drug delivery and the other is the intracellular drug delivery system. The successful application of microneedles which is depends up on the insertion and infusion in to the skin. The other parameters are like stability, sterility, pain, skin irritation and skin infection. But this is a convenient drug delivery for patient appliance and better pharmaceutical option for pharmaceutical‘s drug therapy.

Keywords: Microneedle, Microfabricated device, Ocular drug delivery, Intracellular delivery, Skin infection.