Abstract

AN INNOVATIVE APPROACH OF SPECIAL LAYERED TABLET TECHNOLOGY

Md. Khairul Islam*, Rafiqul Islam, Rokeya Akter, Md. Habibur Rahman and Mahfuza Maharin Shapla

ABSTRACT

Aims: The aim of this research was to describe multiple layered tablet dosage form and their advantages, as well as recent developments in the field of layered tablets, as well as local & globally marketed layer tabled was discussed. Place and Duration of Study: The study was carried out in August 2017 in the Department of Pharmacy, Jagannath University, Dhaka, Bangladesh. Materials & Methods: lactose, Anhydrous Talc, sodium Carboxy methyl cellulose, Carboxy methyl cellulose, Aerosol-200, Mannitol, Sodium Benzoate, PPS, MPS, Polyvinylpyrrolidone K 30, and Maize Starch was used for the production of bi-layered by using of EN SO TROL & OROS Push Pulls Technology. Results & Discussion: Layered Tablet technology was created a new era for the pharmaceutical industry was known as successful drug delivery system which ensured better compliance & convenience. Pharmaceuticals products which given orally are currently available mostly in the immediate release pattern for rapid absorption into the body. Layer tablets were a well-developed product effectively address these issues by including appropriate control strategies and establishing the functional relationships of the material attributes and process parameters critical to the layer tablet quality. Layer matrix tablet was one of the methods which were used for controlled or sustained drug delivery system. Moreover, the ultimate goal was to design controlled or sustained drug delivery system which can reduced the frequency of dosing and providing uniform drug delivery.Conclusion: A well-developed product will effectively address these issues by including appropriate control strategies and establishing the functional relationships of the material attributes and process parameters critical to the layer tablet quality. Hence, layered tablets may be considered as improved beneficial technology to overcome the shortcoming of other tablets.

Keywords: Layered Tablet, OROS, Technology, Compaction, EN SO TROL, L-OROS, Angle of Repose.