WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

A COST EFFECTIVE COMPARISON OF MINOCYCLINE-ER AND ISOTRETINOIN IN MODERATE TO SEVERE ACNE

Dr. Faiz Unnisa Begum*, Pharm D., Dr. Asma Fatima and Dr. Ayesha Butool

ABSTRACT

Background: The purpose of the study is to update the latest developments related to economic evaluation of acne vulgaris and further to present a reference model for the assessment of the cost-effectiveness and treatment of moderate to severe acne vulgaris. Objectives: To determine the most economic & effective drug combination between the two combinations (Isotretinoin + Clindamycin /Minocycline + Clindamycin) in moderate to severe acne vulgaris patients. Methods: A prospective observational comparative study (Cost effectiveness Analysis). In our study we divided 120 acne patients into two groups (Group A and Group B) each containing 60 patients. Group A was prescribed with the combination Isotretinoin + Clindamycin & Group B Minocycline + Clindamycin. We used two different parameters cumulative reduction in grades and lesion score. Comparison of costs and effects were done after complete follow up. Result: A total number of 120 patients were taken into the study and assessed for cost effectiveness. These 120 patients were divided into 2 groups i.e.; Group A (Isotretinoin + Clindamycin) and Group B (Minocycline+ Clindamycin), each group consisting of 60 patients. Different parametric and non parametric tests were applied for statistical evaluation. Paired T- Test was performed to determine the significance of lesion score and t value for group A and group B was found to be 35.953 and 36.117 respectively at 95% confidence interval. Wilcoxon sign rank test was performed to determine the significance of grade score. In both groups, treatment was found to be highly significant in the outcome when compared to baseline. Univariate analysis of covariance (ANCOVA) was performed to compare the efficacy of both the drugs, in relation to lesion score. The actual mean of isotretinoin and minocycline was found to be 2.13 and 3.46 respectively. Ordinal regression test was performed to compare the efficacy of both the treated groups in relation to grade score. It is expressed in the form of marginal percentage. Goodness of fit and Pseudo R square tests were performed. The test was found to be significant. At threshold, 95% confidence interval lower bound was 0.841 and upper bound was found to be 10.561. Compared to Group B, Group A has shown more efficacy and it is also statistically significant. To compare the costs of both the groups, Mann Whitney test was performed. It is measured in mean rank. The mean rank of group A and group B was found to be 28.53 and 84.47 respectively. Cost Effectiveness Ratio with respect to lesion score for isotretinoin and minocycline-ER was found to be 88.233 and 101.89 respectively, and with respect to grade score it was found to be 1002.1 and 1052.4, the drug with least cost effective ratio i.e isotretinoin was found to be more effective. Incremental cost effective ratio for lesion score is -55.177 and grade score is 13408. Therefore, Minocycline was found to be costlier than Isotretinoin. Conclusion: It was concluded that Group A (Isotretinoin+ Clindamycin) combination showed to be more cost effective than Group B (Minocycline+ Clindamycin) based on the clinical and statistical evaluation.

Keywords: Cost-effectiveness, Acne Vulgaris, Patient Counseling, Isotretinoin, Minocycline, Clindamycin.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More