Abstract

THE EFFECT OF TRANS-RESVERATROL THERAPY ON BODY WEIGHT AND BODY HEIGHT IN DIFFERENT AGES OF MALE AND FEMALE THALASSAEMIC PATIENTS

Anirban Roy Chowdhury*, Sudipa Chakravarty and Amit Chakravarty

ABSTRACT

Resveratrol (3,5,4′-trihydroxystilbene), a natural polyphenolic compound found in grapes and red wine, is reported to have beneficial effects on cardiovascular diseases, and enhance of body weight. Resveratrol can help to accumulate the fat deposition into the adipose tissue. Resveratrol may have numerous protective effects against age-related disorders, including renal diseases, through the activation of SIRT1. SIRT1, an NAD+-dependent deacetylase, was identified as one of the molecules through which calorie restriction extends the lifespan or delays age-related diseases, and this protein may regulate multiple cellular functions, including apoptosis, mitochondrial biogenesis, inflammation, glucose/lipid metabolism, autophagy, and adaptations to cellular stress, through the deacetylation of target proteins. In this study we observed the blood CBC parameters of beta and E-beta thalassaemic patients with pre-treatment and post-treatment of trans-resveratrol therapy. We categories the drug response into three groups: Complete Response (52.2%; in patients who can able to maintain at an average Hb level of 6-9 gm/dL without blood transfusion, in this group 12.3% patients are without any previous H/O blood transfusion, others shifted from monthly blood transfusion dependency to a stable transfusion-free condition); Partial Response (18.2%; in patients who remained transfusion dependent but at longer intervals : 2-3 months or more) and Non response (15.9%; in patients who, after more than one year of treatment, remained at the same level of transfusion dependency) the other study we evaluate the effect of trans-resveratrol in body weight and body height in different ages of male and female thalassaemic patients.

Keywords: Resveratrol, ?-thalassemia, Blood transfusion, Good responder, Moderate responder, Non responder. Body height and Body weight.