Abstract

REVIEW ON RUTA GRAVEOLENS

Bharati Hole*, Prajakta Borawade, Shubham Borkar and Annasaheb Gaikwad

ABSTRACT

Bioassay-directed isolation of antifungal compounds from an ethyl acetate extract of Ruta graveolens leaves yielded two furanocoumarins, one quinoline alkaloid, and four quinolone alkaloids including a novel compound, 1-methyl-2-[6-(3,4-methylenedioxyphenyl)hexyl]-4-quinolone. Four of the alkaloids had moderate activity against Colletotrichum species, including a benomyl-resistant C. acutatum. The methanol, petroleum ether, ethyl acetate and water–methanol extracts of Ruta graveolens were found to possess antimicrobial and cytotoxic activities. callus cultures of Ruta graveolens form at least 17 antimicrobial substances some of which were identified. It appeared that acridone alkaloids (rutacridone-epoxide, hydroxyrutacridone -epoxide) are the most active substances against bacteria as well as against fungi. Graphical abstract: Ethyl acetate extract of Ruta graveolens roots yielded rutacridone epoxide with potent selective algicidal activity towards Oscillatoria perornata, with lowest-complete inhibition concentration, LCIC = 0.1 ppm 0.3 μM.

Keywords: Synonynm, biological source, chemical constituents, uses.