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Abstract

SILDENAFIL AMELIORATES CISPLATIN-INDUCED NEPHROTOXICITY IN WISTAR RATS

Ahmed A. Elberry,*, Ameen M. Almohamadi

ABSTRACT

The purpose of this study was to investigate the possible protective effect of SIL against CP-induced nephrotoxicity. Twenty four male Wistar albino rats were classified into four equal groups; normal group, SIL group which received SIL twice (10 mg/kg; i.p. twice; 30 minutes and just before saline administration), CP group which received a single dose of CP (7.5 mg/kg; i.p.) and treated with saline, and CP + SIL group which was treated with the same previous doses. Treatment with SIL was given 2 days before and 4 days after CP administration. On day 4 after CP administration, inulin and para-aminohippurate (PAH) clearances were performed and blood was withdrawn for determination of urea and creatinine. Thereafter, rats were euthanized and kidneys were dissected out for determination of the tissue levels of reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GPx) as well as TNF-α level. CP induced renal injury was evidenced decrease in both inulin and PAH clearances and manifested by significant increase in urea and creatinine levels. Moreover, renal injury was associated with decreased renal tissue activities of SOD, and GPx as well as GSH level. Moreover, renal tissue contents of MDA and TNF-α level were increased. Alterations in these biochemical indices of oxidative stress and inflammation due to CP were attenuated by SIL treatment. In conclusion, SIL treatment can protect rats from CP-induced nephrotoxicity through improving glomerular filtration rate and renal blood flow. This ameliorative effect can be partially attributed to its antioxidant and antiinflamatory effects.

Keywords: The purpose of this study was to investigate the possible protective effect of SIL against CP-induced nephrotoxicity. Twenty four male Wistar albino rats were classified into four equal groups; normal group, SIL group which received SIL twice (10 mg/kg; i


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