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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.485

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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Abstract

QUANTIFICATION OF RIFAXIMIN IN BULK AND PHARMACEUTICAL DOSAGE FORM BY VALIDATED VISIBLE SPECTROPHOTOMETRIC METHODS

Dr. P. G. Sunitha*, E. Senthilkumar, G. Divya, R. Ravikumar, S. Sounthirarajan

ABSTRACT

Two simple sensitive and precise colorimetric methods A and B were developed for the estimation of Rifaximin in bulk drug as well as in pharmaceutical dosage form. Method A is based on the formation of yellow colored chromogen by condensation reaction of Rifaximin with Isoniazid which has absorption maximum at 456nm. Method B is based on the formation of an orange colored complex by oxidation reaction of Rifaximin with 1,10-phenanthroline in the presence of ferric chloride which has absorption maximum at 510nm. The proposed methods are statistically validated and found to be useful for the routine determination of Rifaximin in tablets.

Keywords: Rifaximin, Colorimetry, Tablets, Validation.

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