QUANTIFICATION OF RIFAXIMIN IN BULK AND PHARMACEUTICAL DOSAGE FORM BY VALIDATED VISIBLE SPECTROPHOTOMETRIC METHODS
Dr. P. G. Sunitha*, E. Senthilkumar, G. Divya, R. Ravikumar, S. Sounthirarajan
ABSTRACT
Two simple sensitive and precise colorimetric methods A and B were developed for the estimation of Rifaximin in bulk drug as well as in pharmaceutical dosage form. Method A is based on the formation of yellow colored chromogen by condensation reaction of Rifaximin with Isoniazid which has absorption maximum at 456nm. Method B is based on the formation of an orange colored complex by oxidation reaction of Rifaximin with 1,10-phenanthroline in the presence of ferric chloride which has absorption maximum at 510nm. The proposed methods are statistically validated and found to be useful for the routine determination of Rifaximin in tablets.
Keywords: Rifaximin, Colorimetry, Tablets, Validation.
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