REVIEW ON - BILAYER TABLET
Motarwar S.S.*, Jadhav S.B. ,Kadam V. S. , Muttepawar S.S, Bharkad V.B., Md. Zamiruddin
ABSTRACT
Over the past 30 years as the expense and complications involved in
marketing new drug entities have increased ,with concomitant
recognition of therapeutic advantages of controlled drug delivery,
greater attention has been focused on development of sustained or
controlled release drug delivery system.In the last decade interest in
developing a combination of two or more active pharmaceutical
ingredient(API)in a single dosage form(bilayer tablet)has increased in
the pharmaceutical industry, promoting patient convenience and
compliance. several pharmaceutical companies are currently
developing bilayer tablet for a variety of reason: patentextension, therapeutic ,marketing to
name a few. To reduce capital investment quite often existing but modified tablet presses are
used to develop and such tablets. Bilayer tablet is suitable for sequential release of two drugs
in combination, separate two incompatible substances and also for sustained release tablet in
which one layer is immediate release as initial dose and second layer is
maintenacedose.Bilayer tablet is improved beneficial technology toovercome short coming of
single layer tablet.
Keywords: Bilayer tablet, Approaches, Bilayer tablet presses, GMP requirement for Bilayer Tablets.
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