Abstract

TARGETING GLYCOLYTIC STRESS TO STARVE CANCER CELLS BY SODIUM OXAMATE AND 5-BROMO ISATIN IN URETHANE INDUCED LUNG CARCINOGENESIS

Fayisa K.* and Rajesh V.

ABSTRACT

These studies have provided strong evidence that glycolysis up regulation represents a clear advantage for cancer cells and at the same time a target for new anticancer therapies. Balb/c mice of male sex were divided into 4 groups of 6 animals each. Sodium oxamate and 5-Bromo isatin was evaluated against urethane induced lung carcinogenesis and observed the body weight of animals daily for 26 week. At the end of the study lung tissue were subjected to evaluation for tumor incidence based on morphological and histological study and a portion of lung tissue was subjected to evaluation of parameters of glycolytic stress. Both drugs showed a significant anticancer activity in urethane induced lung carcinogenesis model. The anticancer activity of the sodium oxamate (250 mg/kg) and 5-bromo isatin (50 mg/kg) were found be extremely significant compared to cancer control animals. In treatment group, markers of glycolytic stress were significantly decreased; this might be due to treatment groups less uptake glucose through glycolytic pathway by glycolytic enzyme. Results obtained from the study indicates that sodium oxamate and 5-bromo isatin possess promising anticancer activity The activity might be drug treatment was inhibited glycolytic stress through blockage glycolytic enzymes.

Keywords: Anticancer activity, Glycolytic enzyme inhibitors, Sodium oxamate, 5-bromo isatin, Urethane.