FORMULATION AND IN VITRO EVALUATION OF FLOATING TABLETS OF RANITIDINE HCL USING DIFFERENT POLYMERS
Saurabh Mandowara*, Sanjay K. Sharma, Manish Jaimini, Bhupendra Singh Chauhan, Shailender Mohan
ABSTRACT
The present investigation is an attempt made to develop the floating
tablets of Ranitidine HCl, which after oral administration, prolongs the
gastric residence time and increases the bioavailability of the drug.
Preliminary trial batches were prepared and the best combination was
selected on the basis of the floating behavior (floating lag time, total
floating time). The batches of tablets were fabricated containing drug,
and various grades of polymers viz. HPMC K4M, HPMC K15 M,
HPMC K100M, guar gum and chitosan along with gas generating
agent sodium bicarbonate. The formulations were prepared by using
direct compression technique to study the effect of these polymers on
floating behaviors as well as release. The physicochemical properties
of different formulations, their buoyancy lag time, total floatation time and swelling index
were evaluated. The in vitro release studies indicated that the formulation F6 containing
chitosan with sodium bicarbonate (effervescing compound) showed good drug release rate
marking up to 10 hrs in comparison to other batches. The results indicate that gas powered
hydro-dynamically balanced tablets of Ranitidine HCl containing chitosan provides a better
option for controlled release action and improved bioavailability.
Keywords: Floating drug delivery system, Ranitidine HCl, Hydro-dynamically Balanced System, Bioavailability, Chitosan.
[Download Article]
[Download Certifiate]