Abstract

SYNTHESIS OF NEW THIAZOLE DERIVATIVES AND EVALUATION OF THEIR ANTIMICROBIAL POTENTIAL

Prasad P. Kathade*, Dr. Jagdish R. Baheti, Disha M. Dhabarde and
Pravin K. Bhoyar

ABSTRACT

The new thiazole derivatives (Ia-Ic, IIa-IIc and IIIa-IIIc) has been synthesized as reported in general scheme.In first step substituted acetophenone was allowed to react with bromine in the presence of AlCl3 and ethanol gave various phenacyl bromide derivatives. In second step substituted anilines were reacted with ammonium thiocyanate in the presence of HCL and water which refluxed for about 3-4 hrs gave various derivatives of N-phenyl thiourea. In last step synthesized phenacyl bromide derivatives were refluxed with derivatives of N-phenyl thiourea in the presence of water for given time period. After completion of reaction which was indicated by TLC, the solid was separated and filtered then washed with water. After washing, crude drug obtained was recrystallized from ethanol gave crystals of final derivatives.The synthesized thiazole derivatives were subjected to physicochemical studies like melting point determination, TLC and % yield.The structures of synthesized thiazole derivatives were characterized by spectroscopy, FT-IR spectroscopy, Mass spectroscopy and NMR spectroscopy.Antibacterial screening of newly synthesized compounds (Ia-Ic, IIa-IIc and IIIa-IIIc) was carried out against E. coli, S. aureus and antifungal activity against A. niger according to cup-plate method.The synthesized compounds Ia, Ib, IIa IIc, IIIa, IIIb, IIIc are more effective against S. aureus and E. coli. and Compound IIIc is effective against A. niger.

Keywords: Thiazole, Phenacyl Bromide.