DEVELOPMENT AND EVALUATION OF SUBLINGUAL TABLETS OF TERAZOSIN HYDROCHLORIDE
Satyabrata Bhanja*, K.Lakshmi Deepthi,V.Neelima
ABSTRACT
The objective of the current study was to develop and optimize a
sublingual tablet of Terazosin Hydrochloride, which is an effective
drug in the treatment of Benign Prostate Hyperplasia,
Hypertension. Sublingual tablets of Terazosin Hydrochloride were
prepared by direct compression method using different
superdisintegting agents such as Crospovidone, Sodium starch
glycolate and Croscarmellose sodium. The tablets were evaluated for
pre-compression studies like Bulk density, Tapped density, Carr’s
index, Hausner ratio and post-compression studies like Thickness,
Hardness, Weight variation, Friability, drugcontent, Wetting
time,Water absorption ratio, In-vitro disintegration time, In-vitro
dispersion time, In-vitro dissolution study, drug release kinetic study
and stability study. The Hardness, Weight variation, Thickness, Friability and Drug content
of tablets were found to be acceptable according to United States pharmacopoeial limits. An
optimized formulation i.e. F12 was found, which provided short wetting time of 69±0.8sec,
water absorption ratio of 37.03±0.02%, In-vitro disintegration time of 63±0.8sec, In-vitro
dispersion time of 117±0.6sec respectively.From the above results It indicated that the
amount of superdisinegrant i.e. Crospovidone was significantly affected the dependent
variables like Wetting time, Water absorption ratio, In-vitro disintegration time and In-vitro
dispersion time. The best In-vitro drug release was found to be in formulation F12 i.e. 99.5%
during the end of 10min.Hence the drug release followed the first order Release kinetics with
diffusion mechanism. FT-IR studies shown that there was no interaction between the drug and excipients. The best formulations F12 were subjected to stability studies, which
shown acceptable limits and found to be stable.
Keywords: Sublingual, Wetting time, Water absorption ratio, In-vitro dissolution study.
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