WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • WJPPS: MARCH ISSUE PUBLISHED
  • March Issue has been successfully launched on 1 March 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

Abstract

DEVELOPMENT AND EVALUATION OF SUBLINGUAL TABLETS OF TERAZOSIN HYDROCHLORIDE

Satyabrata Bhanja*, K.Lakshmi Deepthi,V.Neelima

ABSTRACT

The objective of the current study was to develop and optimize a sublingual tablet of Terazosin Hydrochloride, which is an effective drug in the treatment of Benign Prostate Hyperplasia, Hypertension. Sublingual tablets of Terazosin Hydrochloride were prepared by direct compression method using different superdisintegting agents such as Crospovidone, Sodium starch glycolate and Croscarmellose sodium. The tablets were evaluated for pre-compression studies like Bulk density, Tapped density, Carr’s index, Hausner ratio and post-compression studies like Thickness, Hardness, Weight variation, Friability, drugcontent, Wetting time,Water absorption ratio, In-vitro disintegration time, In-vitro dispersion time, In-vitro dissolution study, drug release kinetic study and stability study. The Hardness, Weight variation, Thickness, Friability and Drug content of tablets were found to be acceptable according to United States pharmacopoeial limits. An optimized formulation i.e. F12 was found, which provided short wetting time of 69±0.8sec, water absorption ratio of 37.03±0.02%, In-vitro disintegration time of 63±0.8sec, In-vitro dispersion time of 117±0.6sec respectively.From the above results It indicated that the amount of superdisinegrant i.e. Crospovidone was significantly affected the dependent variables like Wetting time, Water absorption ratio, In-vitro disintegration time and In-vitro dispersion time. The best In-vitro drug release was found to be in formulation F12 i.e. 99.5% during the end of 10min.Hence the drug release followed the first order Release kinetics with diffusion mechanism. FT-IR studies shown that there was no interaction between the drug and excipients. The best formulations F12 were subjected to stability studies, which shown acceptable limits and found to be stable.

Keywords: Sublingual, Wetting time, Water absorption ratio, In-vitro dissolution study.


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More