Abstract

THE EFFECT OF PERINDOPRIL IN HYPERTENSIVE AND TYPE II DIABETES MELLITUS PATIENTS

Manikandan S.*, Ramanathan M. and Vivek R.

ABSTRACT

Today’s big challenge in the medical fraternity is control and management of non-communicable disease. In India the diabetes and hypertension incidence is increasing day by day, to optimize the therapy would be beneficial for patients. The aim of the Study was to evaluate the effect of Perindopril in improving endothelial dysfunction in patient with hypertension and type II diabetes mellitus. This clinical study focus was to assess diameter of brachial artery by flow mediated dilatation (FMD) and endothelial function by microalbuminuria (It is one of the biomarker for endothelial dysfunction). For this study 50 subjects (40 patients and 10 healthy volunteers) were selected based on the inclusion and exclusion criteria (Group B) and (Group A) are enrolled. The patient’s age ranged from 20 to 80 years. Majority of the patients fall between the age group of 41-50 years. The observation ensures Perindopril reduces microalbuminuria and blood pressure to a greater extent in hypertensive and Type II diabetes mellititus patients and thus reduces cardiovascular risk and mortality. Perindopril is found to have no effect on flow mediated dilatation.

Keywords: Perindopril, Endothelial dysfunction, Flow mediated dilatation, Microalbuminuria, cardiovascular risk and mortality.