Abstract

SYNTHESIS AND EVALUATION OF NEW ISATIN DERIVATIVES FOR CYTOTOXIC ACTIVITY

K.Blessi Priyanka, C.Manasa, G.Sammaiah*

ABSTRACT

The objective of the present work is to synthesize a new series of 2(2- oxo-1, 2 –dihydro -indole-3-ylidine) -N- [6(Phenylsulfanyl) -1HBenzimidazole- 2-yl] hydrazine carboxamides and evaluating for cytotoxic activity. All the compounds were screened by MTT assay method. The results of this study revealed that all synthesized compounds significantly cytotoxic in a concentration dependent manner. The IC50 values of all test compounds were found to be between 19.27 and 52.45 mM for MCF-7 cell lines and between 14.10 and 31.6 mM for HeLa cell lines.All the synthesized compounds have shown moderate antioxidant activity.

Keywords: Isatin, cytotoxic, MTT assay, 2(2-oxo-1,2- dihydro -indole -3-ylidine) -N-[6 (Phenylsulfanyl) -1H-benzimidazole-2-yl] hydrazine carboxamides.