Abstract

COMPARATIVE STUDY ON PHYTOCHEMICAL PARAMETERS AND PHARMACOLOGICAL EVALUATION OF WOUND HEALING ACTIVITY ON THE FRUITS AND LEAVES OF GYNOCARDIA ODORATA ROXBURG

Dibya Jyoti Baishya*, Koushik Borah, Dr. Jyotshana Priya Mohanty and Geetanjali Baruah

ABSTRACT

The powdered leaves of Gynocardia odorata is green in color, mild bitter in taste and has characteristics odour while the powdered fruit is brown in colour and has a characteristics taste and odour. Both the powdered leaves and fruits were mounted with chloral hydrate, phloroglucinol, weak iodine and HCL and stained with saffranine, it showed the pressence of starch grains, fragments of vessels, fibres and calcium oxalate crystals. The physicochemical constants like ash value such as total ash, acid insoluble ash, water soluble ash, moisture content, extractive values such as water soluble extractive value and alcohol soluble extractive value were determined for both the leaves and fruits. These helped in formulating pharmacoepoeial standards of the drugs. The extracts obtained by successive solvent extraction of both the leaves and fruits were subjected to preliminary phytochemical analysis which revealed the presence of Flavanoids, Glycosides, Tannins, Saponins, Fixed oils, Fats, Steroids and Triterpenoids. The wound healing activity of aqueous extracts of both the leaves and fruits of the plant Gynocardia odorata was evaluated by Excision wound model in Wister albino Rats. It has been observed that the aqueous extracts of the fruit at a dose level of 10% w/w showed better wound healing activity than that of the aqueous extract of the leaves at the same dose level. This was evident by faster rate of wound closure and epithelization period in excision wound model, but was found to be lesser in comparision to the standard drug povidone iodine.

Keywords: Gynocardia odorata, Leaves, Fruits, Wound, Povidone Iodine.