Abstract

FORMULATION DEVELOPMENT OF EXTENDED RELEASE ACECLOFENAC LOADED EUDRAGIT RSPO MICROPARTICLES THROUGH OPTIMIZATION TECHNIQUE

B. Jayanthi*, S. Sarojini, P. Venkadasan and P. K. Manna

ABSTRACT

The aim of the present study was to develop a central composite design based on response surface methodology to optimize the process parameters for the formulation of extended release aceclofenac microparticles. The micro particle were prepared by emulsion solvent evaporation technique using ethyl cellulose as the polymer a three factors, five levels design of experiments with response surface methodology was employed to study the effect of independent variable stirring speed (X1), viscosity of oil phase(X2) and emulsifying(X3) the dependent variables includes particle size(Y1),drug entrapment efficiency(Y2)and percentage of drug release(Y3).High speed stirring and viscosity of oil phase results in decrease particle size were as viscosity of oil phase increased entrapment efficiency and stirring speed, viscosity oil phase has a positive impact on aceclofenac release over the period of 24hours. Drug-load microparticle exhibited the size ranging between 211.04 μm to 536.83μm with entrapment efficient ranging between 63.93% to 83.65%.and cumulative percentage drug release were ranging between 79.78% to 95.24%.The study helped in predicting the optimized formula with excellent extended drug release. The results obtain indicated that response surface methodology can be successive fully used to optimized the formulation there by reducing the number of trial time and cost of formulation development.

Keywords: Microparticle, Aceclofenac, EudragitRSPO, Response surface methodology, Optimization, Extended Release.