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Abstract

A NEW METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF TELMISARTAN AND RAMIPRIL BY RP-HPLC

B. Raj Kumar*, G. Nagarajan, D. Prashanthi Reddy, E.V.S.Naveen Chowdary, G. Kamalesh, P. Anil Kumar Yadav

ABSTRACT

A simple, precise, rapid and accurate reverse phase HPLC method was developed for the determination of Telmisartan and Ramipril in combined tablet dosage form. A reverse phase C18 column was used as stationary phase of 250x4.6 mm i.d and 5mm partial size, with mobile phase consisting of phosphate buffer of PH 3.0 and acetonitrile in the proportion of 60:40 v/v respectively was used. The flow rate was 1.0 ml/min and the effluents were monitored at 245nm. The retention time was 5.35 and 10.3 minutes. The detector response was linear in the concentration of 16 to 24μg/ml for Telmisartan with 0.9998 as the value of correlation coefficient and for Ramipril the linearity in the range of 2 to 3μg/ml with 0.9998 as the value of correlation coefficient. The Limit of measurements such as limit of detection and limit of quantification were found to be 9.47μg and 31.57μg for Telmisartan and For Ramipril 1.16μg and 3.88μg, respectively. The percentage relative standard deviations for the assay values were found to be 1.11 and 0.518 for Telmisartan and Ramipril. The method was validated by determining its accuracy, precision and system suitability. The results of the study showed that the proposed RP-HPLC method is simple, rapid, precise and accurate. Hence, this method can be easily and conveniently adopted for routine analysis of Telmisartan and Ramipril in combined tablet dosage form.

Keywords: RP-HPLC, LOD, LOQ, Telmisartan, Ramipril.


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