Abstract

THE EVALUATION OF CNS STIMULANT ACTIVITY OF MELOCHIA CORCHORIFOLIA LEAF EXTRACT BY USING DIFFERENT ANIMAL MODELS

*Palaksha M. N., Sahitya P., Sravya P., Mounika P., Ramya P. and Sushmitha P.

ABSTRACT

The aim of the present study was designed to evaluate the CNS Stimulant activities of Melochia corchorifolia using different animal models. CNS stimulant activity was tested using various methods like Photo-actophotometer, Rotarod, Tail Suspension Method. Pharmacological studies have been conducted on the ethanol extracts of Melochia corchorifolia L. leaves to evaluate their effects on the central nervous system (CNS). In photoactometer method, Melochia corchorifolia (200mg/kg p. o.) has exhibited slight decrease in locomotor activity. In rotarod method, Melochia corchorifolia (200mg/kg p.o.) has exhibited slight increase in fall off time, In Tail suspension test Melochia corchorifolia (200mg/kg p.o.) has produced significant reduction in immobility period, when compared with that of animals receiving vehicle. Caffeine was used as a standard and diazepam was used as a negative control. The observations suggest that the extract of Melochia corchorifolia possesses a potent CNS stimulant activity especially in the case of the ethanolic extract. The experimental results conclude that ethanol extract of leaf of the Melochia corchorifolia plant has CNS stimulant activity.

Keywords: Melochia corchorifolia, Actophotometer, Rotarod, Tail Suspension Method, Stimulant.