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Abstract

SYNTHESIS, CHARACTERISATION, ANTIMICROBIAL EVALUATION OF 2-NITRO PHENYL THIAZOLIDINE-4-ONE DERIVATIVE AND 2-NITRO PHENYL AZETIDINE-2-ONE DERIVATIVE

*S. Ramachandran, T. Gangabai, P. Karthika, H. Mohamed Bahat, M. Sathya, M. Yuvaraj and Dr. R. Sundhararajan

ABSTRACT

A new series of 2-nitro phenyl thiazolidine-4-one derivative and 2-nitro phenyl azetidine-2-one derivatives were synthesized by the reaction of schiff base (2 amino pyridine and 2 Nitro benzaldehyde) with mercapto acetic acid and chloro acetyl chloride respectively. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR. The synthesized compounds showed good antibacterial activity against Staphylococcus aureus and Escherichia coli.

Keywords: Antibacterial, Aromatic aldehyde, Pyridine-2-amine, Schiff Bases, Thiazolidine-4-one, Azetidine-2-one.


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