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Abstract

OPTIMIZATION AND EVALUATION OF VALSARTAN FAST DISSOLVING TABLETS- EMPLOYING STARCH GLUTARATE - A NEW SUPERDISINTEGRANT

Dr. A. Bharathi* and D. Chandra Sekhar Naik

ABSTRACT

Valsartan is a Anti-hypertensive drugs which is insoluble in water, hence the drug may be slowly or incompletely dissolves in the gastro-intestinal tract. So the rate of dissolution and therefore its bioavailability is less (bioavailability 23%). The dissolution rate of valsartan can be increased by formulating it into fast dissolving tablets, as these dosage forms disintegrate very rapidly into fine suspension of drug particles resulting in higher surface area of drug. Though, several disintegrants are available, there is continuous need to develop newer disintegrants to have more disintegration and dissolution efficiency. The present research work involves preparation, characterization and
evaluation of starch glutarate as a super disintegrant. The prepared starch glutarate was found to be free flowing and FT-IR revealed the formation of ester. In the present research work, 23 factorial design was used for optimization of level of independent variables (starch glutarate, sodium starch glycolate and croscarmellose sodium) on dependent variables (disintegration time and percent released in 10 minutes) in the formulation Valsartan fast dissolving tablets with less experimentation. From the results it was concluded that starch glutarate, (5%), sodium starch glycolate (5%) and croscarmellose sodium (5%) were favourable for formulation of Valsartan fast dissolving tablets. Therefore, starch glutarate a new modified starch was found to be a promising disintegrant in the formulation of fast dissolving tablets of poorly soluble drugs.

Keywords: Poorly Soluble, valsartan, Starch glutarate.


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