Abstract

AN OVERVIEW OF TARGET DRUG DELIVERY IN CANCER THERAPY

Prashant Verma*, Abhishek Dubey and Prof. Rajeev Shukla

ABSTRACT

Cancer therapies are based on current concepts of molecular biology of cancer. These include antiangiogenic agents, immunotherapy, bacterial agents, viral oncolysis, targeting of cyclic-dependent kinases and tyrosine kinase receptors, antisense approaches, gene therapy and combination of various methods. Methods of immunotherapy in cancer involve use of cytokines, monoclonal antibodies, cancer vaccines and immunogen therepy. Chemotherapy has been the main modality of treatment for cancer patients; however, its success rate remains low, primarily due to limited accessibility of drugs to the tumor tissue, their intolerable toxicity, development of multi-drug resistance, and the dynamic heterogeneous biology of the growing tumors. Better understanding of tumor biology in recent years and new targeted drug delivery approaches that are being explored using different nanosystems and bioconjugates provide optimism in developing successful cancer therapy. This article reviews the possibilities and challenges for targeted drug delivery in cancer therapy.

Keywords: Nanoparticles, Chemotherapy, Tumor cell, Anticancer Agent.