Abstract

PRE-CLINICAL TOXICITY STUDIES OF HOLARRHENA ANTIDYSENTRICA STEM BARK IN MICE AND RATS

Dr. Rajendra Kumar Singh*

ABSTRACT

The present study has been conducted to assess the Pre-Clinical safety of Holarrhena antidysentrica stem bark in mice and rat model. Albino mice (Swiss) were used in graded doses of Holarrhena antidysentrica by oral routes. Acute toxicity of Holarrhena antidysentrica showed normal behaviour and no mortality up to the 14th day. The animal treated with 2000, 1000 & 500 mg/kg, p.o. showed dull, writhing and 30% mortality recorded within 96 h. Effect of Holarrhena antidysentrica on haematological, biochemical and histopathological parameters in sub –acute toxicity was carried out. Sub-acute toxicity of Holarrhena antidysentrica was found no significant changes in haematological, biochemical parameters and histopathological examinations.

Keywords: Holarrhena antidysentrica: Acute- toxicity: Sub- Acute- toxicity: Histopathology.