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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2020
Citation	6651	4087
h-index	26	21
i10-index	174	83

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2025 Issue has been successfully launched on 1 NOVEMBER 2025.

Abstract

RESTORATION OF PATHOLOGICAL CHANGES IN KIDNEY TISSUES FROM DIET INDUCED OBESE RATS TREATED WITH RHINACANTHUS NASUTUS (LINN) KURZ LEAF EXTRACT

D. Sajeda*, L. Lakshaman Kumar, K. Peera and K. Thyaga Raju

ABSTRACT

Obesity is an important cause of kidney diseases and it has close association with diabetes and hypertension and excess weight. The present study was designed to identify the kidney damage like vacuolisation in obesity induced rats and restoration of normaly after treatment with methanolic leaf extract of Rhinacanthus nasutus (R. nasutus). The methanolic leaf extract of R.nasutus (RNME) was orally administered to rats, 200mg/kg/day, while orilistat was administered of 25 mg/kg/day for 6 weeks before being sacrificed. The fat induced vacuolization, glomeruli atrophy of epithelial cells and dark pyknotic nuclei were restored to almost normal upon the treatment of rats with RNME.

Keywords: Obesity, vacuolisation, RNME, glameruli atrophy, pyknotic nuclei, orilistat.

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