Abstract

SYNTHESIS AND IN-VITRO ANTIOXIDANT, ANTICANCER ACTIVITY OF SCHIFF’S BASES AND AZETIDINONE OF 6-ETHOXY 2-AMINO BENZOTHIAZOLE DERIVETIVES

Sathiya A.*, Dr. Sundara Pandian M., Dr. Palanivelu M., Sathya Devi S., Jothirani P., Nagarajan K.

ABSTRACT

A series of Schiff’s base derivatives have been synthesized and incorporated with azetidinone as biologically effective agent with good therapeutic values having minimum toxic levels. 6-ethoxy 2-amino benzothiazole was synthesized from 6-ethoxy aniline by refluxing with ammonium thiocyanate in acidic medium. 6-ethoxy 2- amino benzothiazole was then condensed with various aromatic aldehydes by using ethanol as solvent to yield different Schiff’s bases. Azetidinones derivatives were synthesized from Schiff’s bases in the presences of chloroacetyl chloride, triethylamine and dioxane as solvent. The structures of synthesized compounds were characterized by IR, ¹HNMR and Mass spectral analysis. Purity of the individual compound was confirmed by TLC. The synthesized compounds were evaluated for their in-vitro antioxidant activity and compared with ascorbic acid as standard. The compounds having more antioxidant activity were evaluated for their anticancer activity by Micro culture tetrazolium assay (MTT assay).

Keywords: 6-ethoxy 2-amino benzothiazole, Schiff’s bases, Azetidinones, Antioxidant activity, Anticancer activity.