Abstract

OXIDATION OF PREGABALIN BY POTASSIUM DICHROMATE IN ACID MEDIUM: A KINETIC AND MECHANISTIC STUDY

Syed Yousuf Hussain*, Sayyed Hussain, Mazahar Farooqui and Sayyed Salim

ABSTRACT

Kinetics of oxidation of pregabalin using potassium dichromate as oxidizing agent in acid medium was studied spectrophotometrically at 520 nm. The result interprets that rate of oxidation is first order with respect to potassium dichromate and fractional order with respect to pregabalin where as it does not depend on the concentration of acid. The stoichiometry of the reaction was found that two moles of oxidant is consumed for oxidation of three moles of pregabalin and the product found is 2(2-methyl propyl) butan-di-oic acid. From the results of kinetic studies, reaction stoichiometry and product analysis, the reaction is proposed with suitable mechanism. Based on results of the reaction at different temperatures, the activation parameters with respect to the slow step of the proposed mechanism was calculated.

Keywords: Kinetics, Oxidation, Pregabalin, Potassium Dichromate, Mechanism.