Abstract

REVIEW ON IMMEDIATE RELEASE DRUG DELIVERY SYSTEMS

Sisodiya M. H.* and Saudagar R. B.

ABSTRACT

Many drugs belongs to BCS class2 having poor solubility in water requires enhancement in solubility and dissolution rate for increasing its oral bioavailability, however in many cases immediate onset of action is required than conventional therapy. Tablet is the most popular among all dosage forms existing today because of its convenience of self administration, compactness and easy manufacturing; To overcome these disadvantage, immediate release pharmaceutical dosage form has emerged as alternative oral dosage forms. There are novel types of dosage forms that act very quickly after administration. The basic approach used in development tablets is the use of superdisintegrants which provide instantaneous disintegration of tablet after administration like Cross linked carboxymelhylcellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab), Polyvinylpyrrolidone (Polyplasdone) etc.For treating patients Parenteral dosage form and Immediate release liquid dosage forms have also been establish.Dosage form can be suspensions with typical dispersion agents like hydroxypropylmethylcellulose, (dioctylsulfosuccinate) etc. The growth of immediate release therapy also provides an opportunity for a line extension in the marketplace, A wide range of drugs (e.g., neuroleptics, cardiovascular drugs, analgesics, antihistamines, and drugs can be considered applicant for this dosage form. As a drug entity nears the end of its patent life, it is common for pharmaceutical manufacturers to develop a given drug entity in a new and improved dosage form.

Keywords: Immediate Release Tablet, Superdisintegrants, Polymers.