SYNTHESIS, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL CARBOXAMIDE DERIVATIVES OF NAPROXEN
*Jennifer Fernandes, Abhishek Kumar, Pankaj Kumar, Satyajeet Singh, Bhatt Meet, Bhakta Raju and Jain Mahaveer
ABSTRACT
A series of novel substituted 2-(6-methoxynaphthalen-2-yl)-Nphenylpropanamide
(NAJ1-NAJ8) have been synthesized upon
refluxing 2-(6-methoxynaphthalen-2-yl) propanoic acid with different
substituted anilines in the presence of dry redistilled pyridine and
silicon tetrachloride as coupling reagent. The structures of the final
synthesized compounds were confirmed by IR, 1H NMR and mass
spectra. The synthesized compounds were screened for their antibacterial
and anti-inflammatory activities. The synthesized compounds were
screened for their antibacterial activity against Bacillus subtilis,
Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa
by cup plate method. Compounds NAJ2, NAJ3, NAJ4 and NAJ5 showed
good antibacterial activity compared to the standard drug ciprofloxacin.
Thus some of the amide prodrugs of naproxen showed good antibacterial
activity compared to the parent drug naproxen. The synthesized compounds were screened for
their anti-inflammatory activity by Carrageenan induced paw edema method. The amide
prodrugs of naproxen NAJ1, NAJ3, NAJ4 and NAJ8 showed significant anti-inflammatory
activity compared to the standard drug naproxen.
Keywords: Naproxen, amide prodrugs, antibacterial activity, anti-inflammatory activity.
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