Abstract

ACUTE AND SUB-CHRONIC NEPHROTOXICITY STUDY ON ORALLY ADMINISTERED LEAF EXTRACT OF SPONDIAS MOMBIN IN MALE WISTAR ALBINO RAT

*Nwaogwugwu J. C., Elekwa I., Friday U. O., Okereke C. S., Ezekwe A. S., Egege A. N., and Akara E.

ABSTRACT

Introduction: Spondias mombin has been reported to possess medicinal properties. Method: The preliminary phytochemical analysis was determined by the method described by Harbone 1973 and sofowora, 1982 and the Lethal dose was carried out and median lethal dose was calculated using modified method of Lorke (1983). Twenty five (25) apparently healthy female albino rats aged seven weeks weighing between 76-91g were randomly divided into 5 groups of 5 animals each. Group I served as control, while groups 2, 3, 4 and 5 received the aqueous leaf extract at 200,400,600 and 800 mg/kg body weight respectively. Results: Phytochemical constituent of Spondias mombin was Evaluated and the effects of aqueous leaf extract on some biochemical parameters in albino rats studied. Acute toxicity studies showed that the extract was safe at 500mg/kg body weight dose to albino rats. The results showed that liver enzymes ALT, AST and ALP increased significantly (p

Keywords: .