Abstract

EVALUATION OF IN-VITRO ANTI-CANCER AND ANTIOXIDANT ACTIVITY OF DURVILLAEA ANTARCTICA

Vasthi Kennedy Evanjelene*, Thangavel Subha and Masilamani Gomathi

ABSTRACT

The present study aimed to evaluate its antioxidant and anticancer potential using in vitro assay system using Durvillaea antarctica methanolic extract. Alkaloid, flavonoid, steroids, saponin and carbohydrates were present in the methanol extract. In quantitative system Steroids show higher content when compared to the other phytoconstituents. In vitro, antioxidant activity of the methanol extract was investigated by DPPH radical scavenging assays. Antifungal activity of Durvillaea antarctica was tested for the organisms T.simii, A.niger, C.albicans and C.lunata and the activity compared with the Fucanazole control. Breast cancer (MCF 7) cell line was used as the in vitro cancer model for MTT assay. It can be concluded that Durvillaea antarctica has potential antioxidant and anticancer activities.

Keywords: Sea algae, phytochemical, antifungal, Antioxidant and cell line study.