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Ramachandra M. Koli*, Nitin N. Mali, Sagar S. Kale, Ritesh S. Bathe and Birappa A. Satpute


The present investigation is concerned with development and evalution of Sustained release matrix tablets containing Aceclofenac using the hydrophilic polymer hydroxy propyl methyl cellulose (HPMC) & egg shell powder. Preformulation study was done initially which include characterization of polymers, drug identification, FTIR compatibility and result directed for the further course of formulation. The tablets were prepared by direct compression method and evaluation done. Tablets were compressed by tablet compression machine (Karnavati Rimek Mini press1) and evaluated with different parameters like diameter, thickness, average weight, hardness, friability, drug content, kinetic release data. The in-vitro release studies indicated that the sustained release matrix tablet dosage forms containing higher concentration of HPMC & Egg shell powder showed slower release. Concentration of alone HPMC & Egg shell powder when used significant less % cumulative release are occurs but when used in combination follow better release as required. The in-vitro release data was treated with mathematical equations, and it was concluded that aceclofenac released from the tablet followed zero order model. Hence sustained release drug delivery system of aceclofenac is a promising approach as it can lead to decrease in the frequency of administration and ultimately lead to better patient compliance.

Keywords: Sustained release drug delivery system, aceclofenac, in-vitro drug release. Direct compression method.

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