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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript

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New Impact Factor

WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

Scope Indexed

WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

WJPPS: APRIL ISSUE PUBLISHED

April Issue has been successfully launched on 1 April 2024.

Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIINFLAMMATORY ACTIVITY OF SOME NOVEL QUINOLINE DERIVATIVES

Gunda. Srilakshmi*, Dr. Srinivas R Adapa

ABSTRACT

The Inflammation is a serious health problem in industrialized country due increase in pollution. In the present study a series of new quinoline derivatives (3a-l) were synthesized and evaluated for their anti-inflammatory activity by using the model of carrageenan induced mice paw edema in adult albino rat on comparison with standard Indomethacin. The maximum anti-inflammatory activity was recorded by the compound 3i and 3j having 71% protection of edema followed by compound 3c and 3d showed 69%, compound 3b and 3e having 64% protection of edema. The compound 3i and 3j showed more percentage protection of edema with compared with standard drug Indomethacin (75%). It has been found that the extent of increase in paw volume reduces significantly up to 5 hrs when compared with solvent control.

Keywords: Anti-inflammatory activity, Carrageenan, Indomethacin, Quinoline.

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