Photo Gallery

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • WJPPS Impact Factor
  • Its our Pleasure to Inform you that WJPPS Impact Factor has been increased from  7.454 to 7.632  due to high quality Publication at International Level

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • WJPPS MAY ISSUE PUBLISHED
  • MAY 2020 Issue has been successfully launched on 1 May 2020.

Abstract

INVITRO AND INSILICO ACTIVITIES OF COSTUS IGNEUS LEAF EXTRACTS ON ALPHA AMYLASE - AN ANTIDIABETIC STUDY

Khoushika Raajshree R.* and Chitra P.

ABSTRACT

Diabetes mellitus is a group of metabolic disorders characterized by a chronic hyperglycemic condition due to disturbances in glucose homeostasis. Phytocompounds play a major role in modulating glucose metabolism by inhibition of carbohydrate digesting enzyme like α-amylase. The ethanolic extract of Costus igneus had high invitro α- Amylase inhibition percentage than all other extracts. Gas Chromatography-Mass Spectrometry analysis was performed for the ethanol extract and the compounds obtained were docked against the target Human Pancreatic Alpha-Amylase. Phytol was found to be an active compound through insilico docking with the least E value of – 6.51 kcal/mol. The results are expected to be useful in conducting invivo screenings on animal model which may lead to the development of more effective and potent new chemical entities with antidiabetic property.

Keywords: ?-amylase, Costus igneus, Gas Chromatography-Mass Spectrometry, Phytol, antidiabetic property.


[Full Text Article]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More