Abstract

NEW FORMULATION AND EVALUATION OF DOMPERIDONE SUSPENSION

Saritha Chukka, Shankaraiah Puligilla, Madhusudan Rao Yamsani*

ABSTRACT

Objective of the work was carried out the formulation and evaluation of Domperidone suspension. methods: new formulations were made with the flocculated and deflocculated the domperidone drug suspension with different flocculating agents of AlCl2, Cacl2 and used SLS(formulation code DS1-DS10), HPMC (deflocculating), Sod.CMC(formulation code DN1-DN10) as suspending agents, performed the conductivity studies , stability studies for 6 months, influence of ageing and natural ageing on sedimentation volume, pH, Conductivity and dissolution rate were assessed, Results: results were obtained depending on the concentration of flocculating & suspending agents there was increased sedimentation volume, Conductivity but there is no change on pH, dissolution rate is increased. Conclusion: concluded that the based on the sedimentation volume, rate of settling, ease of redispersibility and optimum release, DN8 & DS10 formulations were selected as best formulations and compared with marketed product Domperidone suspension.

Keywords: Domperidone, flocculating agents, deflocculating agents, dissolution, sedimentation volume, redispersibility.