Abstract

POTENTIAL ROLE OF ZINGIBER CASSUMUNAR ROXB. RHIZOME IN LOWERING BLOOD PRESSURE AND HEART RATE ON FRUCTOSE-INDUCED HYPERTENSION RATS MODEL

Patonah Hasimun*, I. Ketut Adnyana and Fedri Baysar

ABSTRACT

Treatment of hypertension in general needs a longer period of time. The side effects of antihypertensive drugs usually cause a failure of the hypertension treatment. The safety factor long-term drug use is a major concern for any of these medicines. One of the plants that are often used in traditional medicine and has potential as antihypertensive is Zingiber cassumunar Roxb. This study aimed to determine the activity of ethanolic extract of the Zingiber cassumunar Roxb. Rhizome as an antihypertensive. Rats were divided into 6 groups randomly. All groups except the normal group were induced by 25% fructose in the drinking water for 21 consecutive days. Parameters measured were urine volume, systolic and diastolic blood pressure, and heart rate. Ethanol extract of Zingiber cassumunar Roxb. dose of 50 mg/kg showed effective as a diuretic, lowered systolic and diastolic blood pressure and normalize heart rate. Ethanol extract of Zingiber cassumunar Roxb. dose of 50 mg/kg showed the best antihypertension activity.

Keywords: Amlodipine, Fructose, Furosemide, Hypertension, Zingiber cassumunar Roxb.