Abstract

ANTIHYPERGLYCEMIC, ANTIHYPERLIPIDEMIC EFFECTS OF ETHANOL EXTRACT OF NIGELLA SATIVA SEEDS IN STREPTOZOCIN / HIGH FAT DIET INDUCED HYPERGLYCEMIC MICE

Alaa H. Abbas*

ABSTRACT

Objective: The present study was designed to determine the antihyperglycemic and antihyperlipidemic effect of ethanol extract of Nigella sativa seeds, in Streptozocin/high fat diet induced hyperglycemic mice. Materials and methods: The normal serum values of glucose were determined in 40 healthy male mice before Streptozocin/high fat diet induction &at two occasions 14, 28 day after induction by Streptozocin/ high fat diet and treatment with ethanol extract of Nigella sativa seeds for 28 days, also serum C- peptide, cholesterol, triglyceride, VLDL, LDL, HDL are measured at end of experiment. Results: Nigella sativa showed decrease in serum glucose, cholesterol, triglyceride, VLDL, LDL, also increase in serum C- peptide and serum HDL level measured at day 28 compared with glyburide group also, there is improvement in MDA and GSH serum levels.

Keywords: Nigella sativa, Antihyperglycemic, Antihyperlipidemic, STZ, HFD.