Abstract

ANTIHYPERGLYCEMIC EFFECT OF METHANOL EXTRACT OF DRYNARIA QUERCIFOLIA WHOLE PLANT IN GLUCOSE-CHALLENGED MICE

Dipankar Chandra Roy, Tasnim Sultana, Md. Najmul Hossain and Mohammed Rahmatullah*

ABSTRACT

Background: The objective of the present study was to determine the antihyperglycemic effects of methanol extract of Drynaria quercifolia whole plant in glucose-challenged mice. This is a part of our ongoing anti-diabetic project to identify local plant species and plant parts which can lower blood glucose levels, Methods: Antihyperglycemic activity was determined through oral glucose tolerance test (OGTT) in mice. Results: Administration of methanol extract of Drynaria quercifolia whole plant (MEDQ) at doses of 50, 100, 200, and 400 mg per kg body weight each to glucose-loaded mice reduced blood glucose levels by 14.6, 25.4, 31.4, and 39.4%, respectively compared to control (untreated) mice. By comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg body weight, reduced blood glucose level by 40.8%. Conclusion: Methanolic extract of whole plants of Drynaria quercifolia is effective in lowering elevated blood glucose levels, which at the highest dose tested was nearly as effective as glibenclamide.

Keywords: Antihyperglycemic, Drynaria quercifolia, glibenclamide, OGTT.